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Forschung > Schwerpunkte > Akutes Lungenversagen und extrakorporale Lungenersatzverfahren

Akutes Lungenversagen

Das schwere akute Lungenversagen (acute respiratory distress syndrome, ARDS) ist durch eine schwere und anhaltende Störung des pulmonalen Gasaustausches mit konsekutiver Hypoxämie und gleichzeitig bestehender pulmonaler Hypertonie gekennzeichnet.  

Die maschinelle Beatmung ist eine primär unterstützende Therapie bei Patienten mit einem akuten Lungenschaden (= ALI = acute lung injury), die erlaubt einen notwendigen Gasaustausch aufrecht zu erhalten bis die Ursache des Atemversagens korrigiert wurde. Obwohl die maschinelle Beatmung bei diesen Patienten eine lebensrettende Maßnahme darstellt, wurde früh erkannt, dass eine maschinelle Beatmung direkt über verschiedene Mechanismen einen Lungenschaden (Beatmungsinduzierter Lungenschaden = VILI; ventilator induced lung injury) induzieren kann. Diese wurden im Laufe der Jahrzehnte identifiziert:

•  Barotrauma = VILI aufgrund eines hohen Drucks

•  Volutrauma = VILI aufgrund eines hohen Volumens

•  Atelectrauma = VILI durch zyklisches Rekrutieren und Derekrutieren der Alveolen

•  Flowtrauma =  VILI aufgrund eines hohen Atemflusses und hoher Rate an Veränderungen des Lungenvolumens

Alle oben verursachenden Faktoren einer VILI stehen in Verbindung mit den Beatmungseinstellungen, obwohl sie auch während spontaner Atmung auftreten können. Klinisch und tierexperimentell untersuchen wir in unserem ARDS-Zentrum verschiedene Therapieoptionen und mit dem Ziel der Algorithmen für eine differenzierte Therapie zu etablieren.

Aktuelle Projekte

  • Strategien zur Vermeidung Ventilator assoziierter Lungenschäden
  • Interaktion von mechanischer Beatmung und extrakorporalem Lungenersatz 
  • Diagnostik und Therapie alterierter Gerinnungsfunktion unter ECMO-Therapie
  • Evaluation bettseitiger Methoden zur Bestimmung des positiven endexspiratorischen Drucks (PEEP)
  • Etablierung bettseitiger Methoden zur Darstellung regionaler Lungenmechanik mit dem Ziel einer individualisierten lungenprotektiven Beatmung (siehe Forschungsschwerpunkt EIT)

Team

Arbeitsgruppenleiter

Prof. Dr. Michael Quintel

Prof. Dr. Michael Quintel

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Arbeitsgruppenleiter

Prof. Dr. Luciano Gattinoni

Prof. Dr. Luciano Gattinoni

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Arbeitsgruppenleiter

Prof. Dr. Onnen Mörer

Prof. Dr. Onnen Mörer

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Mitglieder

  • M. Busana MD
  • F. Romitti MD
  • R. D'Albo MD
  • A. Fioccola MD
  • I. Fratti MD
  • R. M. Nicolardi MD
  • T. Pozzi MD
  • M. Velati MD
  • Dr. Peter Herrmann
  • Dr. Lars-Olav Harnisch
  • Claudia Ottersbach
  • Thomas Schulze

Externe Mitglieder

  • F. Collino MD
  • T. Tonetti MD

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Aktuelle Doktoranden

  • J. Niewenhuys
  • T. Behnemann

Kooperationen

  • L. Camporota MD Phd
  • D. Chiumello MD
  • J. J. Marini MD

Publikationen

der letzten 9 Jahre

2023

  • Gattarello S, Camporota L, Gattinoni L. COVID-19 pneumonia: Therapeutic implications of its atypical features. Anaesth Crit Care Pain Med. 2023;42(1):101182. doi:10.1016/j.accpm.2022.101182 Impact Factor 7,025
  • David C. Berger, Lena Zwicker, Kay Nettelbeck, Daniela Casoni, 2,Paul Phillipp Heinisch, Hansjörg Jenni, Matthias Haenggi, Luciano Gattinoni, and Kaspar F. Bachmann. Integral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model Am J Physiol Lung Cell Mol Physiol. 2023 Feb 1; 324(2): L102–L113.Published online 2022 Dec 13. doi: 10.1152/ajplung.00045.2022 Impact Factor 3,21
  • Bartlett, Robert H., Carlet, Jean, Cook, Deborah; Gattinoni, Luciano; Harvey, Maurene ; Jacobi, Judith ; Parker, Margaret M.; Sprung, Charles L.; Suter, Peter Suter; Thompson,; Vincent, Jean-Louis.The Impact of the Society of Critical Care Medicine’s Flagship Journal: Critical Care Medicine: Reflections of Critical Care Pioneer Critical Care Medicine 51(2):p 164-181, February 2023. | DOI: 10.1097/CCM.0000000000005728 Impact Factor 9,296
  • Serena Brusatori , Carmelo Zinnato , Mattia Busana , Federica Romitti , Simone Gattarello , Maria Michela Palumbo , Tommaso Pozzi , Irene Steinberg , Paola Palermo , Stefano Lazzari , Roberta Maj ; Mara Velati , Rosanna D'Albo , Jona Wassong , Killian Meissner , Fabio Lombardo , Peter Herrmann , Michael Quintel , Onnen Moerer , Luigi Camporota , John J. Marini , Konrad Meissner , and Luciano Gattinoni. High vs. Low Flow Extracorporeal Respiratory Support in Experimental Hypoxemic Acute Lung Injury American Journal of Respiratory and Critical Care Medicine.DOI :10.1164/rccm.202212 2194OC Impact Factor 30,528
  • Maj R, Palermo P, Gattarello S, Brusatori S, D'Albo R, Zinnato C, Velati M, Romitti F, Busana M, Wieditz J, Herrmann P, Moerer O, Quintel M, Meissner K, Sanderson B, Chiumello D, Marini JJ, Camporota L, Gattinoni L.Ventilatory ratio, dead space, and venous admixture in patients with acute respiratory distress syndrome.Br J Anaesth. 2023 Mar;130(3):360-367. doi: 10.1016/j.bja.2022.10.035 Impact Factor 11,719
  • Luciano Gattinoni , Francesca Collino , Luigi Camporota . Mechanical power: meaning, uses and limitations. Intensive Care Med 2023 Mar 8. doi: 10.1007/s00134-023-06991-3.Impact Factor 41,787
  • Davide Chiumello , Tommaso Pozzi , Elisa Mereto , Isabella Fratti , Elena Chiodaroli ,Luciano Gattinoni , Silvia Coppola January .Author’s response: “Long term feasibility of ultraprotective lung ventilation with low flow extracorporeal carbon dioxide removal (ECCO2R) in ARDS patients”  Journal of Critical Care Impact Factor 4,298
  • Simone Gattarello , Silvia Coppola , Elena Chiodaroli , Tommaso Pozzi , Luigi Camporota , Leif Saager , Davide Chiumello , Luciano Gattinoni .Mechanical Power Ratio and Respiratory Treatment Escalation in COVID-19 Pneumonia: A Secondary Analysis of a Prospectively Enrolled Cohort Anesthesiology 2023 Mar 1;138(3):289-298. DOI: 10.1097/ALN.0000000000004465 Impact Factor 9,198

2022

  • Sandra Rossi, Maria Michela Palumbo, Nicola Sverzellati, Mattia Busana, Laura Malchiodi, Paolo Bresciani, Patrizia Ceccarelli, Emanuele Sani, Federica Romitti, Matteo Bonifazi, Simone Gattarello, Irene Steinberg, Paola Palermo, Stefano Lazzari, Francesca Collino, Massimo Cressoni, Peter Herrmann, Leif Saager, Konrad Meissner, Michael Quintel, Luigi Camporota, John J Marini, Luciano Gattinoni. Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia. Intensive Care Med. 2022 Jan;48(1):56-66. Impact factor: 41.79.
  • Luigi Camporota, John N Cronin, Mattia Busana, Luciano Gattinoni, Federico Formenti. Pathophysiology of coronavirus-19 disease acute lung injury. Curr Opin Crit Care. 2022 Feb 1;28(1):9-16. Impact factor: 3,687.
  • Federica Romitti, Mattia Busana, Maria Michela Palumbo, Matteo Bonifazi, Lorenzo Giosa, Francesco Vassalli, Alessandro Gatta, Francesca Collino, Irene Steinberg, Simone Gattarello, Stefano Lazzari, Paola Palermo, Ahmed Nasr, Ann-Kathrin Gersmann, Annika Richter, Peter Herrmann, Onnen Moerer, Leif Saager, Luigi Camporota, John J Marini, Michael Quintel, Konrad Meissner, Luciano Gattinoni. Mechanical power thresholds during mechanical ventilation: An experimental study. Physiol Rep. 2022 Mar;10(6):e15225. Impact factor: 2,261.
  • Luciano Gattinoni, Luigi Camporota, John J Marini. Prone Position and COVID-19: Mechanisms and Effects. Crit Care Med. 2022 May 1;50(5):873-875. Impact factor: 7,598.
  • Massimo Lamperti, Luciano Gattinoni. Breathing face down. 2022. Br J Anaesth. May;128(5):745-747. Impact factor: 9,872.
  • Luciano Gattinoni, John J Marini. In search of the Holy Grail: identifying the best PEEP in ventilated patients. Intensive Care Med. 2022 Jun;48(6):728-731. Impact factor: 41.79.
  • Philip S Crooke, Luciano Gattinoni, Michael Michalik, John J Marini. Intracycle power distribution in a heterogeneous multi-compartmental mathematical model: possible links to strain and VILI. Intensive Care Med Exp. 2022 Jun 1;10(1):21. Impact factor: N/A.
  • Mattia Busana, Luigi Camporota, Luciano Gattinoni. Hypoxaemia in COVID-19: many pieces to a complex puzzle. Eur Respir Rev. 2022 Jun 28;31(164):220090. Impact factor: 9,553.
  • Irene Steinberg, Iacopo Pasticci, Mattia Busana, Andrea Costamagna, Günter Hahn, Simone Gattarello, Paola Palermo, Stefano Lazzari, Federica Romitti, Peter Herrmann, Onnen Moerer, Leif Saager, Konrad Meissner, Michael Quintel, Luciano Gattinoni. Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury. Crit Care Med. 2022 Jul 1;50(7):e630-e637. Impact factor: 7,598.
  • John Selickman, Pierre Tawfik, Philip S Crooke, David J Dries, Jonathan Shelver, Luciano Gattinoni, John J Marini. Paradoxical response to chest wall loading predicts a favorable mechanical response to reduction in tidal volume or PEEP. Crit Care. 2022 Jul 5;26(1):201. Impact factor: 9.097.
  • Thomas Langer, Serena Brusatori, Luciano Gattinoni. Understanding base excess (BE): merits and pitfalls. Intensive Care Med. 2022 Aug;48(8):1080-1083. Impact factor: 41.79.
  • Mattia Busana, Luigi Camporota, Luciano Gattinoni. Biochemical shunt: where and how? Eur Respir Rev. 2022 Sep 20;31(165):220148. Impact factor: 9,553.
  • Irene Telias, Laurent J Brochard, Simone Gattarello, Hannah Wunsch, Detajin Junhasavasdikul, Karen J Bosma, Luigi Camporota, Daniel Brodie, John J Marini, Arthur S Slutsky, Luciano Gattinoni. The physiological underpinnings of life-saving respiratory support. Intensive Care Med. 2022 Oct;48(10):1274-1286. Impact factor: 41.79.
  • Davide Chiumello, Tommaso Pozzi, Elisa Mereto, Isabella Fratti, Elena Chiodaroli, Luciano Gattinoni, Silvia Coppola. Long term feasibility of ultraprotective lung ventilation with low-flow extracorporeal carbon dioxide removal in ARDS patients. J Crit Care. 2022 Oct;71:154092. Impact factor: 3.425.
  • Luciano Gattinoni, Silvia Coppola, Luigi Camporota. Physiology of extracorporeal CO2 removal. Intensive Care Med. 2022 Oct;48(10):1322-1325. Impact factor: 41.79.
  • Stefano Lazzari, Federica Romitti, Mattia Busana, Francesco Vassalli, Matteo Bonifazi, Matteo Maria Macrí, Lorenzo Giosa, Francesca Collino, Daniel Heise, Martin Golinski, Simone Gattarello, Lars-Olav Harnisch, Serena Brusatori, Roberta Maj, Carmelo Zinnato, Konrad Meissner, Michael Quintel, Onnen Moerer, John J Marini, Barnaby Sanderson, Luigi Camporota, Luciano Gattinoni. End-Tidal to Arterial Pco2 Ratio as Guide to Weaning from Venovenous Extracorporeal Membrane Oxygenation. Am J Respir Crit Care Med.  2022 Oct 15;206(8):973-980. Impact factor: 30.528.
  • John Selickman, Philip S Crooke, Pierre Tawfik, David J Dries, Luciano Gattinoni, John J Marini. Paradoxical Positioning: Does "Head Up" Always Improve Mechanics and Lung Protection? Crit Care Med. 2022 Nov 1;50(11):1599-1606. Impact factor: 7,598.
  • Mattia Busana, Carmelo Zinnato, Federica Romitti, Michela Palumbo, Simone Gattarello, Aurelio Sonzogni, Ann-Kathrin Gersmann, Annika Richter, Peter Herrmann, Günter Hahn, Serena Brusatori, Roberta Maj, Mara Velati, Onnen Moerer, Konrad Meissner, Tom Barnes, Michael Quintel, John J Marini, Luciano Gattinoni. Energy dissipation during expiration and ventilator-induced lung injury: an experimental animal study. J Appl Physiol (1985). 2022 Nov 1;133(5):1212-1219. Impact factor 3.880.
  • Roberta Maj, Paola Palermo, Simone Gattarello, Serena Brusatori, Rosanna D'Albo, Carmelo Zinnato, Mara Velati, Federica Romitti, Mattia Busana, Johannes Wieditz, Peter Herrmann, Onnen Moerer, Micheal Quintel, Konrad Meissner, Barnaby Sanderson, Davide Chiumello, John J Marini, Luigi Camporota, Luciano Gattinoni. Ventilatory ratio, dead space, and venous admixture in acute respiratory distress syndrome. Br J Anaesth. 2022 Dec 2;S0007-0912(22)00624-9. Impact factor: 9,872.
  • Simone Gattarello Silvia Coppola; Elena Chiodaroli; Tommaso Pozzi; Luigi Camporota; Leif Saager; Davide Chiumello; Luciano Gattinoni. Mechanical power ratio and respiratory treatment escalation in covid 19 pneumonia: a secondary analysis of a prospectively enrolled cohort. Accepted in Anaesthesiology, (pending publication). Impact factor: 7.892.
  • David Berger, Lena Zwicker, Kay Nettelbeck, Daniela Casoni, Paul Heinisch, Hansjörg Jenni, Matthias Haenggi, Luciano Gattinoni, and Kaspar Bachmann. Integral Assessment of Gas Exchange During Veno-Arterial ECMO - Accuracy and Precision of a Modified Fick Principle in a Porcine Model. Accepted in: J Appl Physiol (1985) (pending publication). Impact factor: 3.880.
  • Simone Gattarello; Luigi Camporota; Luciano Gattinoni. COVID-19 pneumonia: therapeutic implications of its atypical features. Accepted in: Anaesthesia, Critical Care & Pain Medicine (pending publication). Impact factor: 4.132.
     

2021

  • Acute respiratory distress syndrome. Meyer NJ, Gattinoni L, Calfee CS. Lancet. 2021 Aug 14;398(10300):622-637. doi: 10.1016/S0140-6736(21)00439-6. Epub 2021 Jul 1.PMID: 34217425 Free PMC article. Review Impact Factor 202,7
  • Pathophysiology of COVID-19-associated acute respiratory distress syndrome. Camporota L, Chiumello D, Busana M, Gattinoni L, Marini JJ. Lancet Respir Med. 2021 Jan;9(1):e1. doi: 10.1016/S2213-2600(20)30505-1. Epub 2020 Nov 13.PMID: 33197391 Free PMC article. Impact Factor 102,642
  • COVID-19 pneumonia: pathophysiology and management. Gattinoni L, Gattarello S, Steinberg I, Busana M, Palermo P, Lazzari S, Romitti F, Quintel M, Meissner K, Marini JJ, Chiumello D, Camporota L. Eur Respir Rev. 2021 Oct 20;30(162):210138. doi: 10.1183/16000617.0138-2021. Print 2021 Dec 31.PMID: 34670808 Free PMC article. Review Impact Factor 9,553
  • Personalized mechanical ventilation in acute respiratory distress syndrome. Pelosi P, Ball L, Barbas CSV, Bellomo R, Burns KEA, Einav S, Gattinoni L, Laffey JG, Marini JJ, Myatra SN, Schultz MJ, Teboul JL, Rocco PRM Crit Care. 2021 Jul 16;25(1):250. doi: 10.1186/s13054-021-03686-3.PMID: 34271958 Free PMC article. Review Impact Factor 19,344
  • COVID-19 and ARDS: the baby lung size matters. Gattinoni L, Busana M, Camporota L, Marini JJ, Chiumello D Intensive Care Med. 2021 Jan;47(1):133-134. doi: 10.1007/s00134-020-06324-8. Epub 2020 Dec 4.PMID: 33275164 Free PMC article. No abstract available. Impact Factor 41,787
  • Improving lung compliance by external compression of the chest wall. Marini JJ, Gattinoni L. Crit Care. 2021 Jul 28;25(1):264. doi: 10.1186/s13054-021-03700-8.PMID: 34321060 Free PMC article. Review. Impact Factor 19,344
  • Prevalence and outcome of silent hypoxemia in COVID-19. Busana M, Gasperetti A, Giosa L, Forleo GB, Schiavone M, Mitacchione G, Bonino C, Villa P, Galli M, Tondo C, Saguner A, Steiger P, Curnis A, Dello Russo A, Pugliese F, Mancone M, Marini JJ, Gattinoni L. Minerva Anestesiol. 2021 Mar;87(3):325-333. doi: 10.23736/S0375-9393.21.15245-9.PMID: 33694360 Free article. Impact Factor 3,396
  • The impact of ventilation-perfusion inequality in COVID-19: a computational model. Busana M, Giosa L, Cressoni M, Gasperetti A, Di Girolamo L, Martinelli A, Sonzogni A, Lorini L, Palumbo MM, Romitti F, Gattarello S, Steinberg I, Herrmann P, Meissner K, Quintel M, Gattinoni L. J Appl Physiol (1985). 2021 Mar 1;130(3):865-876. doi: 10.1152/japplphysiol.00871.2020. Epub 2021 Jan 13.PMID: 33439790 Free PMC article. Impact Factor 3,532
  • Conceptual simplicity in pursuit of precision. Marini JJ, Crooke PS, Gattinoni L. Intensive Care Med. 2021 Aug;47(8):920-921.  doi: 10.1007/s00134-021-06424-z. Epub 2021 Jun 16.PMID: 34132842 No abstract available. Impact Factor 41,787
  • Mobilizing Carbon Dioxide Stores. An Experimental Study. Giosa L, Busana M, Bonifazi M, Romitti F, Vassalli F, Pasticci I, Macrì MM, D'Albo R, Collino F, Gatta A, Palumbo MM, Herrmann P, Moerer O, Iapichino G, Meissner K, Quintel M, Gattinoni L Am J Respir Crit Care Med. 2021 Feb 1;203(3):318-327. doi: 10.1164/rccm.202005-1687OC.PMID: 32813989 Impact Factor 30,528
  • Complexity and unanswered questions in the pathophysiology of COVID-19 ARDS. Chiumello D, Camporota L, Gattinoni L, Marini JJ. Intensive Care Med. 2021 Apr;47(4):495-496. doi: 10.1007/s00134-021-06353-x. Epub 2021 Feb 1.PMID: 33527153 Free PMC article. Impact Factor 41,787
  • Standardised PaO2/FiO2 ratio in COVID-19: Added value or risky assumptions? Gattinoni L, Busana M, Camporota L.Eur J Intern Med. 2021 Oct;92:31-33. doi: 10.1016/j.ejim.2021.09.004. Epub 2021 Sep 9.PMID: 34526222 Free PMC article. No abstract available Impact Factor 7.749
  • Intra-cycle power: is the flow profile a neglected component of lung protection? Marini JJ, Crooke PS, Gattinoni L.Intensive Care Med. 2021 May;47(5):609-611. doi: 10.1007/s00134-021-06375-5. Epub 2021 Apr 2.PMID: 33797574 Free PMC article. No abstract available. Impact Factor 41.787
  • [Randomized controlled multicenter study of albumin replacement therapy in septic shock (ARISS)]. Sakr Y, Gattinoni L; SepNet-Critical-Care-Trials-Gruppe. Anaesthesist. 2021 Jun;70(6):528-530. doi: 10.1007/s00101-021-00952-5. Epub 2021 Mar 31.PMID: 33787990 Free PMC article. German. Impact Factor 
  • The 4DPRR Index and Mechanical Power: A Step Ahead or Four Steps Backward? Camporota L, Busana M, Marini JJ, Gattinoni L.Am J Respir Crit Care Med. 2021 Aug 15;204(4):491-492. doi: 10.1164/rccm.202104-0923LE.PMID: 34081879 Free PMC article. No abstract available. Impact Factor 30,528
  • Role of total lung stress on the progression of early COVID-19 pneumonia. Coppola S, Chiumello D, Busana M, Giola E, Palermo P, Pozzi T, Steinberg I, Roli S, Romitti F, Lazzari S, Gattarello S, Palumbo M, Herrmann P, Saager L, Quintel M, Meissner K, Camporota L, Marini JJ, Centanni S, Gattinoni L. Intensive Care Med. 2021 Oct;47(10):1130-1139. doi: 10.1007/s00134-021-06519-7. Epub 2021 Sep 16.PMID: 34529118 Impact Factor 41,787
  • Role of Fluid and Sodium Retention in Experimental Ventilator-Induced Lung Injury. Gattarello S, Pasticci I, Busana M, Lazzari S, Palermo P, Palumbo MM, Romitti F, Steinberg I, Collino F, Vassalli F, Langer T, Moerer O, Saager L, Herrmann P, Cadringher P, Meissner K, Quintel M, Gattinoni L.Front Physiol. 2021 Sep 13;12:743153. doi: 10.3389/fphys.2021.743153. eCollection 2021.PMID: 34588999 Free PMC article. Impact Factor 4,566
  • Albumin Oxidation Status in Sepsis Patients Treated With Albumin or Crystalloids. Bonifazi M, Meessen J, Pérez A, Vasques F, Busana M, Vassalli F, Novelli D, Bernasconi R, Signori C, Masson S, Romitti F, Giosa L, Macrì M, Pasticci I, Palumbo MM, Mota F, Costa M, Caironi P, Latini R, Quintel M, Gattinoni L.Front Physiol. 2021 Aug 6;12:682877. doi: 10.3389/fphys.2021.682877. eCollection 2021.PMID: 34447316 Free PMC article. Impact Factor 4,566
  • Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study. Pham T, Pesenti A, Bellani G, Rubenfeld G, Fan E, Bugedo G, Lorente JA, Fernandes ADV, Van Haren F, Bruhn A, Rios F, Esteban A, Gattinoni L, Larsson A, McAuley DF, Ranieri M, Thompson BT, Wrigge H, Brochard LJ, Laffey JG; LUNG SAFE Investigators and the European Society of Intensive Care Medicine Trials Group. Eur Respir J. 2021 Jun 10;57(6):2003317. doi: 10.1183/13993003.03317-2020. Print 2021 Jun.PMID: 33334944 Impact Factor
  • Intracycle power and ventilation mode as potential contributors to ventilator-induced lung injury. Marini JJ, Crooke PS, Tawfik P, Chatburn RL, Dries DJ, Gattinoni L.Intensive Care Med Exp. 2021 Nov 1;9(1):55. doi: 10.1186/s40635-021-00420-9.PMID: 34719749 Free PMC article. Impact Factor
  • Reply to Tobin et al.: Respiratory Drive Measurements Do Not Signify Conjectural Patient Self-inflicted Lung Injury. Gattinoni L, Marini JJ, Camporota L.Am J Respir Crit Care Med. 2021 Jan 1;203(1):143-144. doi: 10.1164/rccm.202009-3692LE.PMID: 33064951 Free PMC article. No abstract available. Impact Factor 30,528
  • End-tidal to arterial PCO2 ratio: a bedside meter of the overall gas exchanger performance. Bonifazi M, Romitti F, Busana M, Palumbo MM, Steinberg I, Gattarello S, Palermo P, Saager L, Meissner K, Quintel M, Chiumello D, Gattinoni L. Intensive Care Med Exp. 2021 Apr 19;9(1):21. doi: 10.1186/s40635-021-00377-9.PMID: 33871738 Free PMC article. Impact Factor
  • Using Artificial Intelligence for Automatic Segmentation of CT Lung Images in Acute Respiratory Distress Syndrome. Herrmann P, Busana M, Cressoni M, Lotz J, Moerer O, Saager L, Meissner K, Quintel M, Gattinoni L. Front Physiol. 2021 Sep 14;12:676118. doi: 10.3389/fphys.2021.676118. eCollection 2021.PMID: 34594233 Free PMC article. Impact Factor 4,566
  • Low noncarbonic buffer power amplifies acute respiratory acid-base disorders in patients with sepsis: an in vitro study. Langer T, Brusatori S, Carlesso E, Zadek F, Brambilla P, Ferraris Fusarini C, Duska F, Caironi P, Gattinoni L, Fasano M, Lualdi M, Alberio T, Zanella A, Pesenti A, Grasselli G.J Appl Physiol (1985). 2021 Aug 1;131(2):464-473. doi: 10.1152/japplphysiol.00787.2020. Epub 2021 Jun 17.PMID: 34138647 Impact Factor 3,532
  • "Established" Respiratory Treatment in Acute Respiratory Distress Syndrome: Scientific Rigor or a Square Peg in a Round Hole? Camporota L, Gattinoni L, Marini JJ. Am J Respir Crit Care Med. 2021 Mar 15;203(6):779. doi: 10.1164/rccm.202011-4163LE.PMID: 33320794 Free PMC article. No abstract available. Impact Factor 30,528
  • Ihalationally Administered Semifluorinated Alkanes (SFAs) as Drug Carriers in an Experimental Modeln of Acute Respiratory Distress Syndrome. Otto M, Krebs J, Welker P, Holm R, Thiel M, Gattinoni L, Quintel M, Tsagogiorgas C Pharmaceutics. 2021 Mar 23;13(3):431. doi: 10.3390/pharmaceutics13030431.PMID: 33806903 Free PMC article. Impact Factor 6,525
  • Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS. Piotti A, Novelli D, Meessen JMTA, Ferlicca D, Coppolecchia S, Marino A, Salati G, Savioli M, Grasselli G, Bellani G, Pesenti A, Masson S, Caironi P, Gattinoni L, Gobbi M, Fracasso C, Latini R; ALBIOS Investigators Crit Care. 2021 Mar 19;25(1):113. doi: 10.1186/s13054-021-03545-1.PMID: 33741039 Free PMC article. Clinical Trial. Impact Factor 19,344
  • Isn't it time to abandon ARDS? The COVID-19 lesson L Gattinoni 1 2, J J Marini 3 4 Crit Care 2021 Sep 6;25(1):326. doi: 10.1186/s13054-021-03748-6. PMID: 34488807 Impact Factor 19,344

2020

2019

  • Combes A, Fanelli V, Pham T, Ranieri VM; European Society of Intensive Care. Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO(2) removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med. 2019 Feb 21. doi: 10.1007/s00134-019-05567-4.
  • Moerer O, Harnisch LO, Barwing J, Heise D, Heuer JF, Quintel M. Minimal-flow ECCO(2)R in patients needing CRRT does not facilitate lung-protective ventilation. J Artif Organs. 2019 Mar;22(1):68-76. doi:10.1007/s10047-018-1068-8
  • Collino F, Rapetti F, Vasques F, Maiolo G, Tonetti T, Romitti F, Niewenhuys J, Behnemann T, Camporota L, Hahn G, Reupke V, Holke K, Herrmann P, Duscio E, Cipulli F, Moerer O, Marini JJ, Quintel M, Gattinoni L. Positive End-expiratory Pressure and Mechanical Power. Anesthesiology. 2019 Jan;130(1):119-130. doi:10.1097/ALN.0000000000002458.
  • Coppola S, Froio S, Marino A, Brioni M, Cesana BM, Cressoni M, Gattinoni L, Chiumello D. Respiratory Mechanics, Lung Recruitability, and Gas Exchange in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome. Crit Care Med. 2019 Mar 22. doi: 10.1097/CCM.0000000000003715.
  • Grasselli G, Scaravilli V, Tubiolo D, Russo R, Crimella F, Bichi F, Corinna Morlacchi L, Scotti E, Patrini L, Gattinoni L, Pesenti A, Chiumello D. Quality of Life and Lung Function in Survivors of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. Anesthesiology. 2019 Apr;130(4):572-580. doi: 10.1097/ALN.0000000000002624.
  • Duscio E, Cipulli F, Vasques F, Collino F, Rapetti F, Romitti F, Behnemann T, Niewenhuys J, Tonetti T, Pasticci I, Vassalli F, Reupke V, Moerer O, Quintel M, Gattinoni L. Extracorporeal CO2 Removal: The Minimally Invasive Approach, Theory and Practice. Crit Care Med. 2019 Jan;47(1):33-40. doi:
  • Heuer JF, Mirschel M, Bleckmann A, Quintel M, Moerer O. Interhospital transport of ARDS patients on extracorporeal membrane oxygenation. J Artif Organs. 2019 Mar;22(1):53-60. doi: 10.1007/s10047-018-1065-y.

2018

  • Fichtner F, Moerer O, Laudi S, Weber-Carstens S, Nothacker M, Kaisers U; Investigators and the Guideline Group on Mechanical Ventilation and Extracorporeal Membrane Oxygena tion in Acute Respiratory Insufficiency. Mechanical Ventilation and Extracorporeal Membrane Oxygena tion in Acute Respiratory Insufficiency. Dtsch Arztebl Int. 2018 Dec 14;115(50):840-847. doi:10.3238/arztebl.2018.0840.
  • Gattinoni L, Vassalli F, Romitti F. Benefits and risks of the P/F approach. Intensive Care Med. 2018 Dec;44(12):2245-2247. doi: 10.1007/s00134-018-5413-4.
  • Husain-Syed F, Ricci Z, Brodie D, Vincent JL, Ranieri VM, Slutsky AS, Taccone FS, Gattinoni L, Ronco C. Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk. Intensive Care Med. 2018 Sep;44(9):1447-1459. doi: 10.1007/s00134-018-5329-z.
  • Marini JJ, Gattinoni L. Protecting the Ventilated Lung: Vascular Surge and Deflation Energetics. Am J Respir Crit Care Med. 2018 Nov 1;198(9):1112-1114. doi: 10.1164/rccm.201806-1082ED.
  • Kollisch-Singule MC, Jain SV, Andrews PL, Satalin J, Gatto LA, Villar J, De Backer D, Gattinoni L, Nieman GF, Habashi NM. Last Word on Viewpoint: Looking beyond macrovenitlatory parameters and rethinking ventilator-induced lung injury. J Appl Physiol (1985). 2018 May 1;124(5):1220-1221. doi:10.1152/japplphysiol.00049.2018.
  • Cipulli F, Vasques F, Duscio E, Romitti F, Quintel M, Gattinoni L. Atelectrauma or volutrauma: the dilemma. J Thorac Dis. 2018 Mar;10(3):1258-1264. doi: 10.21037/jtd.2018.02.71.
  • Marini JJ, Gattinoni L. Energetics and the Root Mechanical Cause for Ventilator-induced Lung Injury. Anesthesiology. 2018 Jun;128(6):1062-1064. doi: 10.1097/ALN.0000000000002203. PubMed PMID: 29620572.
  • Cressoni M, Chiurazzi C, Chiumello D, Gattinoni L. Does high PEEP prevent alveolar cycling? Med Klin Intensivmed Notfmed. 2018 Feb;113(Suppl 1):7-12. doi: 10.1007/s00063-017-0375-9.
  • Vasques F, Duscio E, Pasticci I, Romitti F, Vassalli F, Quintel M, Gattinoni L. Is the mechanical power the final word on ventilator-induced lung injury?-we are not sure. Ann Transl Med. 2018 Oct;6(19):395. doi: 10.21037/atm.2018.08.17.
  • Gattinoni L, Quintel M, Marini JJ. Volutrauma and atelectrauma: which is worse? Crit Care. 2018 Oct 25;22(1):264. doi: 10.1186/s13054-018-2199-2.
  • Gattinoni L, Vasques F, Quintel M. Use of ECMO in ARDS: does the EOLIA trial really help? Crit Care. 2018 Jul 5;22(1):171. doi: 10.1186/s13054-018-2098-6.
  • Moerer O, Vasques F, Duscio E, Cipulli F, Romitti F, Gattinoni L, Quintel M. Extracorporeal Gas Exchange. Crit Care Clin. 2018 Jul;34(3):413-422. doi: 10.1016/j.ccc.2018.03.011.
  • Vasques F, Duscio E, Cipulli F, Romitti F, Quintel M, Gattinoni L. Determinants and Prevention of Ventilator-Induced Lung Injury. Crit Care Clin. 2018 Jul;34(3):343-356. doi: 10.1016/j.ccc.2018.03.004.
  • Klapsing P, Moerer O, Wende C, Herrmann P, Quintel M, Bleckmann A, Heuer JF. High-frequency oscillatory ventilation guided by transpulmonary pressure in acute respiratory syndrome: an experimental study in pigs. Crit Care. 2018 May 9;22(1):121. doi: 10.1186/s13054-018-2028-7.
  • Cortes-Puentes GA, Gard KE, Adams AB, Dries DJ, Quintel M, Oeckler RA, Gattinoni L, Marini JJ. Positional effects on the distributions of ventilation and end-expiratory gas volume in the asymmetric chest-a quantitative lung computed tomographic analysis. Intensive Care Med Exp. 2018 Apr 10;6(1):9. doi:
  • Dodoo-Schittko F, Brandstetter S, Brandl M, Blecha S, Quintel M, Weber-Carstens S, Kluge S, Kirschning T, Muders T, Bercker S, Ellger B, Arndt C, Meybohm P, Adamzik M, Goldmann A, Karagiannidis C, Bein T, Apfelbacher C; DACAPO Study Group. German-wide prospective DACAPO cohort of survivors of the acute respiratory distress syndrome (ARDS): a cohort profile. BMJ Open. 2018 Apr 4;8(4):e019342. doi: 10.1136/bmjopen-2017-019342.
  • Gattinoni L, Marini JJ, Quintel M. Time to Rethink the Approach to Treating Acute Respiratory Distress Syndrome. JAMA. 2018 Feb 20;319(7):664-666. doi: 10.1001/jama.2017.21900. PubMed PMID: 29466572.
  • Brodie D, Vincent JL, Brochard LJ, Combes A, Ferguson ND, Hodgson CL, Laffey JG, Mercat A, Pesenti A, Quintel M, Slutsky AS, Ranieri VM; International ECMO Network (ECMONet). Research in Extracorporeal Life Support: A Call to Action. Chest. 2018 Apr;153(4):788-791. doi: 10.1016/j.chest.2017.12.024.
  • Maiolo G, Collino F, Vasques F, Rapetti F, Tonetti T, Romitti F, Cressoni M, Chiumello D, Moerer O, Herrmann P, Friede T, Quintel M, Gattinoni L. Reclassifying Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Jun 15;197(12):1586-1595. doi: 10.1164/rccm.201709-1804OC.
  • Blecha S, Dodoo-Schittko F, Brandstetter S, Brandl M, Dittmar M, Graf BM, Karagiannidis C, Apfelbacher C, Bein T; DACAPO Study Group. Quality of inter-hospital transportation in 431 transport survivor patients suffering from acute respiratory distress syndrome referred to specialist centers. Ann Intensive Care. 2018 Jan 15;8(1):5. doi: 10.1186/s13613-018-0357-y.
  • Gattinoni L, Quintel M. New insights in mechanical ventilation. Med Klin Intensivmed Notfmed. 2018 Feb;113(Suppl 1):1. doi: 10.1007/s00063-017-0393-7. PubMed PMID: 29318327.

2017

  • Gattinoni L, Tonetti T, Quintel M. Regional physiology of ARDS. Crit Care. 2017 Dec 28;21(Suppl 3):312. doi: 10.1186/s13054-017-1905-9.
  • Bellingan G, Brealey D, Mancebo J, Mercat A, Patroniti N, Pettilä V, Quintel M, Vincent JL, Maksimow M, Jalkanen M, Piippo I, Ranieri VM. Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial. Trials. 2017 Nov 13;18(1):536. doi: 10.1186/s13063-017-2234-7.
  • Gattinoni L, Quintel M. Do we need randomized clinical trials in extracorporeal respiratory support? No. Intensive Care Med. 2017 Dec;43(12):1866-1868. doi: 10.1007/s00134-017-4826-9.
  • Tonetti T, Vasques F, Rapetti F, Maiolo G, Collino F, Romitti F, Camporota L, Cressoni M, Cadringher P, Quintel M, Gattinoni L. Driving pressure and mechanical power: new targets for VILI prevention. Ann Transl Med. 2017 Jul;5(14):286. doi: 10.21037/atm.2017.07.08.
  • Gattinoni L, Collino F, Maiolo G, Rapetti F, Romitti F, Tonetti T, Vasques F, Quintel M. Positive end-expiratory pressure: how to set it at the individual level. Ann Transl Med. 2017 Jul;5(14):288. doi: 10.21037/atm.2017.06.64.
  • Klapsing P, Herrmann P, Quintel M, Moerer O. Automatic quantitative computed tomography segmentation and analysis of aerated lung volumes in acute respiratory distress syndrome-A comparative diagnostic study. J Crit Care. 2017 Dec;42:184-191. doi: 10.1016/j.jcrc.2016.11.001.
  • Brodie D, Curtis JR, Vincent JL, Bakker J, Brown CE, Creteur J, Papazian L, Sladen RN, Ranieri VM; participants in the Round Table Conference. Treatment limitations in the era of ECMO. Lancet Respir Med. 2017 Oct;5(10):769-770. doi: 10.1016/S2213-2600(17)30263-1.
  • Gattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M. The future of mechanical ventilation: lessons from the present and the past. Crit Care. 2017 Jul 12;21(1):183. doi: 10.1186/s13054-017-1750-x.
  • Raymondos K, Dirks T, Quintel M, Molitoris U, Ahrens J, Dieck T, Johanning K, Henzler D, Rossaint R, Putensen C, Wrigge H, Wittich R, Ragaller M, Bein T, Beiderlinden M, Sanmann M, Rabe C, Schlechtweg J, Holler M, Frutos-Vivar F, Esteban A, Hecker H, Rosseau S, von Dossow V, Spies C, Welte T, Piepenbrock S, Weber-Carstens S. Outcome of acute respiratory distress syndrome in university and non-university hospitals in Germany. Crit Care. 2017 May 30;21(1):122. doi:10.1186/s13054-017-1687-0.
  • Dodoo-Schittko F, Brandstetter S, Brandl M, Blecha S, Quintel M, Weber-Carstens S, Kluge S, Meybohm P, Rolfes C, Ellger B, Bach F, Welte T, Muders T, Thomann-Hackner K, Bein T, Apfelbacher C. Characteristics and provision of care of patients with the acute respiratory distress syndrome: descriptive findings from the DACAPO cohort baseline and comparison with international findings. J Thorac Dis. 2017 Mar;9(3):818-830. doi: 10.21037/jtd.2017.03.120.
  • Gattinoni L, Tonetti T, Quintel M. Intensive care medicine in 2050:ventilator-induced lung injury. Intensive Care Med. 2018 Jan;44(1):76-78. doi:10.1007/s00134-017-4770-8.
  • Gattinoni L, Marini JJ, Quintel M. Evidence or belief-based medicine? Ten doubts. Intensive Care Med. 2017 Sep;43(9):1392-1394. doi:10.1007/s00134-017-4724-1.
  • Tonetti T, Cressoni M, Collino F, Maiolo G, Rapetti F, Quintel M, Gattinoni L. Volutrauma, Atelectrauma, and Mechanical Power. Crit Care Med. 2017 Mar;45(3):e327-e328. doi: 10.1097/CCM.0000000000002193.
  • Moerer O, Tonetti T, Quintel M. Rescue therapies for acute respiratory distress syndrome: what to try first? Curr Opin Crit Care. 2017 Feb;23(1):52-59. doi: 10.1097/MCC.0000000000000374.
  • Gattinoni L, Tonetti T, Quintel M. How best to set the ventilator on extracorporeal membrane lung oxygenation. Curr Opin Crit Care. 2017 Feb;23(1):66-72. doi: 10.1097/MCC.0000000000000376.
  • Blanch L, Quintel M. Lung-brain cross talk in the critically ill. Intensive Care Med. 2017 Apr;43(4):557-559. doi: 10.1007/s00134-016-4583-1. Epub 2016 Oct 6. Review. PubMed PMID: 27714405.
  • Quintel M, Tonetti T, Gattinoni L. Will all ARDS patients be receiving mechanical ventilation in 2035? We are not sure. Intensive Care Med. 2017 Apr;43(4):573-574. doi: 10.1007/s00134-016-4456-7
  • Cambiaghi B, Vasques F, Mörer O, Ritter C, Mauri T, Kunze-Szikszay N, Holke K, Collino F, Maiolo G, Rapetti F, Schulze-Kalthoff E, Tonetti T, Hahn G, Quintel M, Gattinoni L. Effects of regional perfusion block in healthy and injured lungs. Intensive Care Med Exp. 2017 Oct 13;5(1):46. doi: 10.1186/s40635-017-0161-2.
  • Del Sorbo L, Goligher EC, McAuley DF, Rubenfeld GD, Brochard LJ, Gattinoni L, Slutsky AS, Fan E. Mechanical Ventilation in Adults with Acute Respiratory Distress Syndrome. Summary of the Experimental Evidence for the Clinical Practice Guideline. Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S261-S270. doi: 10.1513/AnnalsATS.201704-345OT.
  • Dong M, Zhou Y, Kang Y, Cressoni M, Chiumello D, Gattinoni L. Discussion on "Opening pressures and atelectrauma in acute respiratory distress syndrome". Intensive Care Med. 2017 Dec;43(12):1936-1937. doi: 10.1007/s00134-017-4944-4. Epub 2017 Sep 26.

2016

  • Schoehl J, Mechie NC, Schwoerer H, Moerer O, Quintel M, Buck C, Ellenrieder V, Neesse A, Amanzada A. Severe Acute Respiratory Distress Syndrome during Infliximab Therapy in a Patient with Crohn Disease. Case Rep Gastroenterol. 2016 Oct 18;10(3):574-580.
  • Gattinoni L, Quintel M. Fifty Years of Research in ARDS Why Is Acute Respiratory Distress Syndrome So Important for Critical Care? Am J Respir Crit Care Med. 2016 Nov 1;194(9):1051-1052. Review. PubMed PMID: 27797616.
  • Serpa Neto A, Schmidt M, Azevedo LC, Bein T, Brochard L, Beutel G, Combes A, Costa EL, Hodgson C, Lindskov C, Lubnow M, Lueck C, Michaels AJ, Paiva JA, Park M, Pesenti A, Pham T, Quintel M, Marco Ranieri V, Ried M, Roncon-Albuquerque R Jr, Slutsky AS, Takeda S, Terragni PP, Vejen M, Weber-Carstens S, Welte T, Gama de Abreu M, Pelosi P, Schultz MJ; ReVA Research Network and the PROVE Network Investigators. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: Mechanical ventilation during ECMO. Intensive Care Med. 2016 Nov;42(11):1672-1684.
  • Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, Protti A, Gotti M, Chiurazzi C, Carlesso E, Chiumello D, Quintel M. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med. 2016 Oct;42(10):1567-1575. doi: 10.1007/s00134-016-4505-2.
  • Quintel M, Gattinoni L, Weber-Carstens S. The German ECMO inflation: when things other than health and care begin to rule medicine. Intensive Care Med. 2016 Aug;42(8):1264-6. doi: 10.1007/s00134-016-4380-x. Epub 2016 Jun 6. PubMed PMID: 27272677.
  • Gattinoni L, Quintel M. How ARDS should be treated. Crit Care. 2016 Apr 6;20:86. doi: 10.1186/s13054-016-1268-7. PubMed PMID: 27048605; PubMed Central PMCID: PMC4822276.
  • Bein T, Grasso S, Moerer O, Quintel M, Guerin C, Deja M, Brondani A, Mehta S. The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia. Intensive Care Med. 2016 May;42(5):699-711. doi: 10.1007/s00134-016-4325-4.
  • Pesenti A, Musch G, Lichtenstein D, Mojoli F, Amato MBP, Cinnella G, Gattinoni L, Quintel M. Imaging in acute respiratory distress syndrome. Intensive Care Med. 2016 May;42(5):686-698. doi: 10.1007/s00134-016-4328-1.
  • Fan E, Gattinoni L, Combes A, Schmidt M, Peek G, Brodie D, Muller T, Morelli A, Ranieri VM, Pesenti A, Brochard L, Hodgson C, Van Kiersbilck C, Roch A, Quintel M, Papazian L. Venovenous extracorporeal membrane oxygenation for acute respiratory failure : A clinical review from an international group of experts. Intensive Care Med. 2016 May;42(5):712-724. doi: 10.1007/s00134-016-4314-7.
  • Moerer O, Quintel M. Bridge or Abyss: Extracorporeal Membrane Oxygenation for Acute Respiratory Failure in Interstitial Lung Disease. Am J Respir Crit Care Med. 2016 Mar 1;193(5):474-6. doi: 10.1164/rccm.201511-2184ED. PubMed PMID: 26930427.
  • Gattinoni L, Quintel M. Is mechanical ventilation a cure for ARDS? Intensive Care Med. 2016 May;42(5):916-917. doi: 10.1007/s00134-016-4266-y. Epub 2016 Feb 18. PubMed PMID: 26891674.
  • Fanelli V, Ranieri MV, Mancebo J, Moerer O, Quintel M, Morley S, Moran I, Parrilla F, Costamagna A, Gaudiosi M, Combes A. Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome. Crit Care. 2016 Feb 10;20:36. doi: 10.1186/s13054-016-1211-y.
  • Gattinoni L, Marini JJ, Pesenti A, Quintel M, Mancebo J, Brochard L. The "baby lung" became an adult. Intensive Care Med. 2016 May;42(5):663-673. doi:10.1007/s00134-015-4200-8.

2015

  • Brandstetter S, Dodoo-Schittko F, Blecha S, Sebök P, Thomann-Hackner K, Quintel M, Weber-Carstens S, Bein T, Apfelbacher C. Influence of quality of care and individual patient characteristics on quality of life and return to work in survivors of the acute respiratory distress syndrome: protocol for a prospective, observational, multi-centre patient cohort study (DACAPO). BMC Health Serv Res. 2015 Dec 17;15:563. doi: 10.1186/s12913-015-1232-2. PubMed PMID: 26677970; PubMed Central PMCID: PMC4683730.
  • Moerer O, Brodie D, Quintel M. Low-Flow Extracorporeal Carbon Dioxide Removal. Moving Closer to Reality. Am J Respir Crit Care Med. 2015 Sep 15;192(6):651-2. doi: 10.1164/rccm.201506-1181ED. PubMed PMID: 26371808.
  • Riech S, Kallenberg K, Moerer O, Hellen P, Bärtsch P, Quintel M, Knauth M. The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema. Crit Care Med. 2015 Sep;43(9):e386-9. doi: 10.1097/CCM.0000000000001150. PubMed PMID: 26110491.
  • Caironi P, Carlesso E, Cressoni M, Chiumello D, Moerer O, Chiurazzi C, Brioni M, Bottino N, Lazzerini M, Bugedo G, Quintel M, Ranieri VM, Gattinoni L. Lung recruitability is better estimated according to the Berlin definition of acute respiratory distress syndrome at standard 5 cm H2O rather than higher positive end-expiratory pressure: a retrospective cohort study. Crit Care Med. 2015 Apr;43(4):781-90. doi: 10.1097/CCM.0000000000000770.

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