Akutes Lungenversagen

Das schwere akute Lungenversagen (acute respiratory distress syndrome, ARDS) ist durch eine schwere und anhaltende Störung des pulmonalen Gasaustausches mit konsekutiver Hypoxämie und gleichzeitig bestehender pulmonaler Hypertonie gekennzeichnet.  

Die maschinelle Beatmung ist eine primär unterstützende Therapie bei Patienten mit einem akuten Lungenschaden (= ALI = acute lung injury), die erlaubt einen notwendigen Gasaustausch aufrecht zu erhalten bis die Ursache des Atemversagens korrigiert wurde. Obwohl die maschinelle Beatmung bei diesen Patienten eine lebensrettende Maßnahme darstellt, wurde früh erkannt, dass eine maschinelle Beatmung direkt über verschiedene Mechanismen einen Lungenschaden (Beatmungsinduzierter Lungenschaden = VILI; ventilator induced lung injury) induzieren kann. Diese wurden im Laufe der Jahrzehnte identifiziert:

•  Barotrauma = VILI aufgrund eines hohen Drucks

•  Volutrauma = VILI aufgrund eines hohen Volumens

•  Atelectrauma = VILI durch zyklisches Rekrutieren und Derekrutieren der Alveolen

•  Flowtrauma =  VILI aufgrund eines hohen Atemflusses und hoher Rate an Veränderungen des Lungenvolumens

Alle oben verursachenden Faktoren einer VILI stehen in Verbindung mit den Beatmungseinstellungen, obwohl sie auch während spontaner Atmung auftreten können. Klinisch und tierexperimentell untersuchen wir in unserem ARDS-Zentrum verschiedene Therapieoptionen und mit dem Ziel der Algorithmen für eine differenzierte Therapie zu etablieren.

Aktuelle Projekte

  • Strategien zur Vermeidung Ventilator assoziierter Lungenschäden
  • Interaktion von mechanischer Beatmung und extrakorporalem Lungenersatz 
  • Diagnostik und Therapie alterierter Gerinnungsfunktion unter ECMO-Therapie
  • Evaluation bettseitiger Methoden zur Bestimmung des positiven endexspiratorischen Drucks (PEEP)
  • Etablierung bettseitiger Methoden zur Darstellung regionaler Lungenmechanik mit dem Ziel einer individualisierten lungenprotektiven Beatmung (siehe Forschungsschwerpunkt EIT)

Team

Arbeitsgruppenleiter

Prof. Dr. Michael Quintel

Kontaktinformationen

Arbeitsgruppenleiter

Prof. Dr. Luciano Gattinoni

Kontaktinformationen

Arbeitsgruppenleiter

Prof. Dr. Onnen Mörer

Kontaktinformationen

Mitglieder

  • Dr. F. Romitti
  • Dr. F Vasques
  • Dr. F. Vassalli
  • Dr. E. Duscio
  • Dr. I. Pasticci
  • Dr. P. Herrmann
  • Thomas Schulze
  • Dr. med. J-O. Harnisch
  • C. Ottersbach
  • A. Gorin

Externe Mitglieder

  • PD Dr. JF Heuer
  • Dr. F. Vasques
  • Dr. T. Tonetti
  • Dr. F. Cipull
  • Dr. L Camporota

Aktuelle Doktoranden

  • Niewenhuys J
  • Behnemann T

Kooperationen

  • Prof. Dr. VM Ranieri
  • Prof. Dr. JJ Marini
  • Prof. Dr. D. Chiumello
  • Prof. Dr. C. Karagiannidis
  • Prof. Dr. T. Bein

Publikationen

der letzten 5 Jahre

2019

  • Combes A, Fanelli V, Pham T, Ranieri VM; European Society of Intensive Care. Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO(2) removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med. 2019 Feb 21. doi: 10.1007/s00134-019-05567-4.
  • Moerer O, Harnisch LO, Barwing J, Heise D, Heuer JF, Quintel M. Minimal-flow ECCO(2)R in patients needing CRRT does not facilitate lung-protective ventilation. J Artif Organs. 2019 Mar;22(1):68-76. doi:10.1007/s10047-018-1068-8
  • Collino F, Rapetti F, Vasques F, Maiolo G, Tonetti T, Romitti F, Niewenhuys J, Behnemann T, Camporota L, Hahn G, Reupke V, Holke K, Herrmann P, Duscio E, Cipulli F, Moerer O, Marini JJ, Quintel M, Gattinoni L. Positive End-expiratory Pressure and Mechanical Power. Anesthesiology. 2019 Jan;130(1):119-130. doi:10.1097/ALN.0000000000002458.
  • Coppola S, Froio S, Marino A, Brioni M, Cesana BM, Cressoni M, Gattinoni L, Chiumello D. Respiratory Mechanics, Lung Recruitability, and Gas Exchange in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome. Crit Care Med. 2019 Mar 22. doi: 10.1097/CCM.0000000000003715.
  • Grasselli G, Scaravilli V, Tubiolo D, Russo R, Crimella F, Bichi F, Corinna Morlacchi L, Scotti E, Patrini L, Gattinoni L, Pesenti A, Chiumello D. Quality of Life and Lung Function in Survivors of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. Anesthesiology. 2019 Apr;130(4):572-580. doi: 10.1097/ALN.0000000000002624.
  • Duscio E, Cipulli F, Vasques F, Collino F, Rapetti F, Romitti F, Behnemann T, Niewenhuys J, Tonetti T, Pasticci I, Vassalli F, Reupke V, Moerer O, Quintel M, Gattinoni L. Extracorporeal CO2 Removal: The Minimally Invasive Approach, Theory and Practice. Crit Care Med. 2019 Jan;47(1):33-40. doi:
  • Heuer JF, Mirschel M, Bleckmann A, Quintel M, Moerer O. Interhospital transport of ARDS patients on extracorporeal membrane oxygenation. J Artif Organs. 2019 Mar;22(1):53-60. doi: 10.1007/s10047-018-1065-y.

2018

  • Fichtner F, Moerer O, Laudi S, Weber-Carstens S, Nothacker M, Kaisers U; Investigators and the Guideline Group on Mechanical Ventilation and Extracorporeal Membrane Oxygena tion in Acute Respiratory Insufficiency. Mechanical Ventilation and Extracorporeal Membrane Oxygena tion in Acute Respiratory Insufficiency. Dtsch Arztebl Int. 2018 Dec 14;115(50):840-847. doi:10.3238/arztebl.2018.0840.
  • Gattinoni L, Vassalli F, Romitti F. Benefits and risks of the P/F approach. Intensive Care Med. 2018 Dec;44(12):2245-2247. doi: 10.1007/s00134-018-5413-4.
  • Husain-Syed F, Ricci Z, Brodie D, Vincent JL, Ranieri VM, Slutsky AS, Taccone FS, Gattinoni L, Ronco C. Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk. Intensive Care Med. 2018 Sep;44(9):1447-1459. doi: 10.1007/s00134-018-5329-z.
  • Marini JJ, Gattinoni L. Protecting the Ventilated Lung: Vascular Surge and Deflation Energetics. Am J Respir Crit Care Med. 2018 Nov 1;198(9):1112-1114. doi: 10.1164/rccm.201806-1082ED.
  • Kollisch-Singule MC, Jain SV, Andrews PL, Satalin J, Gatto LA, Villar J, De Backer D, Gattinoni L, Nieman GF, Habashi NM. Last Word on Viewpoint: Looking beyond macrovenitlatory parameters and rethinking ventilator-induced lung injury. J Appl Physiol (1985). 2018 May 1;124(5):1220-1221. doi:10.1152/japplphysiol.00049.2018.
  • Cipulli F, Vasques F, Duscio E, Romitti F, Quintel M, Gattinoni L. Atelectrauma or volutrauma: the dilemma. J Thorac Dis. 2018 Mar;10(3):1258-1264. doi: 10.21037/jtd.2018.02.71.
  • Marini JJ, Gattinoni L. Energetics and the Root Mechanical Cause for Ventilator-induced Lung Injury. Anesthesiology. 2018 Jun;128(6):1062-1064. doi: 10.1097/ALN.0000000000002203. PubMed PMID: 29620572.
  • Cressoni M, Chiurazzi C, Chiumello D, Gattinoni L. Does high PEEP prevent alveolar cycling? Med Klin Intensivmed Notfmed. 2018 Feb;113(Suppl 1):7-12. doi: 10.1007/s00063-017-0375-9.
  • Vasques F, Duscio E, Pasticci I, Romitti F, Vassalli F, Quintel M, Gattinoni L. Is the mechanical power the final word on ventilator-induced lung injury?-we are not sure. Ann Transl Med. 2018 Oct;6(19):395. doi: 10.21037/atm.2018.08.17.
  • Gattinoni L, Quintel M, Marini JJ. Volutrauma and atelectrauma: which is worse? Crit Care. 2018 Oct 25;22(1):264. doi: 10.1186/s13054-018-2199-2.
  • Gattinoni L, Vasques F, Quintel M. Use of ECMO in ARDS: does the EOLIA trial really help? Crit Care. 2018 Jul 5;22(1):171. doi: 10.1186/s13054-018-2098-6.
  • Moerer O, Vasques F, Duscio E, Cipulli F, Romitti F, Gattinoni L, Quintel M. Extracorporeal Gas Exchange. Crit Care Clin. 2018 Jul;34(3):413-422. doi: 10.1016/j.ccc.2018.03.011.
  • Vasques F, Duscio E, Cipulli F, Romitti F, Quintel M, Gattinoni L. Determinants and Prevention of Ventilator-Induced Lung Injury. Crit Care Clin. 2018 Jul;34(3):343-356. doi: 10.1016/j.ccc.2018.03.004.
  • Klapsing P, Moerer O, Wende C, Herrmann P, Quintel M, Bleckmann A, Heuer JF. High-frequency oscillatory ventilation guided by transpulmonary pressure in acute respiratory syndrome: an experimental study in pigs. Crit Care. 2018 May 9;22(1):121. doi: 10.1186/s13054-018-2028-7.
  • Cortes-Puentes GA, Gard KE, Adams AB, Dries DJ, Quintel M, Oeckler RA, Gattinoni L, Marini JJ. Positional effects on the distributions of ventilation and end-expiratory gas volume in the asymmetric chest-a quantitative lung computed tomographic analysis. Intensive Care Med Exp. 2018 Apr 10;6(1):9. doi:
  • Dodoo-Schittko F, Brandstetter S, Brandl M, Blecha S, Quintel M, Weber-Carstens S, Kluge S, Kirschning T, Muders T, Bercker S, Ellger B, Arndt C, Meybohm P, Adamzik M, Goldmann A, Karagiannidis C, Bein T, Apfelbacher C; DACAPO Study Group. German-wide prospective DACAPO cohort of survivors of the acute respiratory distress syndrome (ARDS): a cohort profile. BMJ Open. 2018 Apr 4;8(4):e019342. doi: 10.1136/bmjopen-2017-019342.
  • Gattinoni L, Marini JJ, Quintel M. Time to Rethink the Approach to Treating Acute Respiratory Distress Syndrome. JAMA. 2018 Feb 20;319(7):664-666. doi: 10.1001/jama.2017.21900. PubMed PMID: 29466572.
  • Brodie D, Vincent JL, Brochard LJ, Combes A, Ferguson ND, Hodgson CL, Laffey JG, Mercat A, Pesenti A, Quintel M, Slutsky AS, Ranieri VM; International ECMO Network (ECMONet). Research in Extracorporeal Life Support: A Call to Action. Chest. 2018 Apr;153(4):788-791. doi: 10.1016/j.chest.2017.12.024.
  • Maiolo G, Collino F, Vasques F, Rapetti F, Tonetti T, Romitti F, Cressoni M, Chiumello D, Moerer O, Herrmann P, Friede T, Quintel M, Gattinoni L. Reclassifying Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Jun 15;197(12):1586-1595. doi: 10.1164/rccm.201709-1804OC.
  • Blecha S, Dodoo-Schittko F, Brandstetter S, Brandl M, Dittmar M, Graf BM, Karagiannidis C, Apfelbacher C, Bein T; DACAPO Study Group. Quality of inter-hospital transportation in 431 transport survivor patients suffering from acute respiratory distress syndrome referred to specialist centers. Ann Intensive Care. 2018 Jan 15;8(1):5. doi: 10.1186/s13613-018-0357-y.
  • Gattinoni L, Quintel M. New insights in mechanical ventilation. Med Klin Intensivmed Notfmed. 2018 Feb;113(Suppl 1):1. doi: 10.1007/s00063-017-0393-7. PubMed PMID: 29318327.

2017

  • Gattinoni L, Tonetti T, Quintel M. Regional physiology of ARDS. Crit Care. 2017 Dec 28;21(Suppl 3):312. doi: 10.1186/s13054-017-1905-9.
  • Bellingan G, Brealey D, Mancebo J, Mercat A, Patroniti N, Pettilä V, Quintel M, Vincent JL, Maksimow M, Jalkanen M, Piippo I, Ranieri VM. Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial. Trials. 2017 Nov 13;18(1):536. doi: 10.1186/s13063-017-2234-7.
  • Gattinoni L, Quintel M. Do we need randomized clinical trials in extracorporeal respiratory support? No. Intensive Care Med. 2017 Dec;43(12):1866-1868. doi: 10.1007/s00134-017-4826-9.
  • Tonetti T, Vasques F, Rapetti F, Maiolo G, Collino F, Romitti F, Camporota L, Cressoni M, Cadringher P, Quintel M, Gattinoni L. Driving pressure and mechanical power: new targets for VILI prevention. Ann Transl Med. 2017 Jul;5(14):286. doi: 10.21037/atm.2017.07.08.
  • Gattinoni L, Collino F, Maiolo G, Rapetti F, Romitti F, Tonetti T, Vasques F, Quintel M. Positive end-expiratory pressure: how to set it at the individual level. Ann Transl Med. 2017 Jul;5(14):288. doi: 10.21037/atm.2017.06.64.
  • Klapsing P, Herrmann P, Quintel M, Moerer O. Automatic quantitative computed tomography segmentation and analysis of aerated lung volumes in acute respiratory distress syndrome-A comparative diagnostic study. J Crit Care. 2017 Dec;42:184-191. doi: 10.1016/j.jcrc.2016.11.001.
  • Brodie D, Curtis JR, Vincent JL, Bakker J, Brown CE, Creteur J, Papazian L, Sladen RN, Ranieri VM; participants in the Round Table Conference. Treatment limitations in the era of ECMO. Lancet Respir Med. 2017 Oct;5(10):769-770. doi: 10.1016/S2213-2600(17)30263-1.
  • Gattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M. The future of mechanical ventilation: lessons from the present and the past. Crit Care. 2017 Jul 12;21(1):183. doi: 10.1186/s13054-017-1750-x.
  • Raymondos K, Dirks T, Quintel M, Molitoris U, Ahrens J, Dieck T, Johanning K, Henzler D, Rossaint R, Putensen C, Wrigge H, Wittich R, Ragaller M, Bein T, Beiderlinden M, Sanmann M, Rabe C, Schlechtweg J, Holler M, Frutos-Vivar F, Esteban A, Hecker H, Rosseau S, von Dossow V, Spies C, Welte T, Piepenbrock S, Weber-Carstens S. Outcome of acute respiratory distress syndrome in university and non-university hospitals in Germany. Crit Care. 2017 May 30;21(1):122. doi:10.1186/s13054-017-1687-0.
  • Dodoo-Schittko F, Brandstetter S, Brandl M, Blecha S, Quintel M, Weber-Carstens S, Kluge S, Meybohm P, Rolfes C, Ellger B, Bach F, Welte T, Muders T, Thomann-Hackner K, Bein T, Apfelbacher C. Characteristics and provision of care of patients with the acute respiratory distress syndrome: descriptive findings from the DACAPO cohort baseline and comparison with international findings. J Thorac Dis. 2017 Mar;9(3):818-830. doi: 10.21037/jtd.2017.03.120.
  • Gattinoni L, Tonetti T, Quintel M. Intensive care medicine in 2050:ventilator-induced lung injury. Intensive Care Med. 2018 Jan;44(1):76-78. doi:10.1007/s00134-017-4770-8.
  • Gattinoni L, Marini JJ, Quintel M. Evidence or belief-based medicine? Ten doubts. Intensive Care Med. 2017 Sep;43(9):1392-1394. doi:10.1007/s00134-017-4724-1.
  • Tonetti T, Cressoni M, Collino F, Maiolo G, Rapetti F, Quintel M, Gattinoni L. Volutrauma, Atelectrauma, and Mechanical Power. Crit Care Med. 2017 Mar;45(3):e327-e328. doi: 10.1097/CCM.0000000000002193.
  • Moerer O, Tonetti T, Quintel M. Rescue therapies for acute respiratory distress syndrome: what to try first? Curr Opin Crit Care. 2017 Feb;23(1):52-59. doi: 10.1097/MCC.0000000000000374.
  • Gattinoni L, Tonetti T, Quintel M. How best to set the ventilator on extracorporeal membrane lung oxygenation. Curr Opin Crit Care. 2017 Feb;23(1):66-72. doi: 10.1097/MCC.0000000000000376.
  • Blanch L, Quintel M. Lung-brain cross talk in the critically ill. Intensive Care Med. 2017 Apr;43(4):557-559. doi: 10.1007/s00134-016-4583-1. Epub 2016 Oct 6. Review. PubMed PMID: 27714405.
  • Quintel M, Tonetti T, Gattinoni L. Will all ARDS patients be receiving mechanical ventilation in 2035? We are not sure. Intensive Care Med. 2017 Apr;43(4):573-574. doi: 10.1007/s00134-016-4456-7
  • Cambiaghi B, Vasques F, Mörer O, Ritter C, Mauri T, Kunze-Szikszay N, Holke K, Collino F, Maiolo G, Rapetti F, Schulze-Kalthoff E, Tonetti T, Hahn G, Quintel M, Gattinoni L. Effects of regional perfusion block in healthy and injured lungs. Intensive Care Med Exp. 2017 Oct 13;5(1):46. doi: 10.1186/s40635-017-0161-2.
  • Del Sorbo L, Goligher EC, McAuley DF, Rubenfeld GD, Brochard LJ, Gattinoni L, Slutsky AS, Fan E. Mechanical Ventilation in Adults with Acute Respiratory Distress Syndrome. Summary of the Experimental Evidence for the Clinical Practice Guideline. Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S261-S270. doi: 10.1513/AnnalsATS.201704-345OT.
  • Dong M, Zhou Y, Kang Y, Cressoni M, Chiumello D, Gattinoni L. Discussion on "Opening pressures and atelectrauma in acute respiratory distress syndrome". Intensive Care Med. 2017 Dec;43(12):1936-1937. doi: 10.1007/s00134-017-4944-4. Epub 2017 Sep 26.

2016

  • Schoehl J, Mechie NC, Schwoerer H, Moerer O, Quintel M, Buck C, Ellenrieder V, Neesse A, Amanzada A. Severe Acute Respiratory Distress Syndrome during Infliximab Therapy in a Patient with Crohn Disease. Case Rep Gastroenterol. 2016 Oct 18;10(3):574-580.
  • Gattinoni L, Quintel M. Fifty Years of Research in ARDS Why Is Acute Respiratory Distress Syndrome So Important for Critical Care? Am J Respir Crit Care Med. 2016 Nov 1;194(9):1051-1052. Review. PubMed PMID: 27797616.
  • Serpa Neto A, Schmidt M, Azevedo LC, Bein T, Brochard L, Beutel G, Combes A, Costa EL, Hodgson C, Lindskov C, Lubnow M, Lueck C, Michaels AJ, Paiva JA, Park M, Pesenti A, Pham T, Quintel M, Marco Ranieri V, Ried M, Roncon-Albuquerque R Jr, Slutsky AS, Takeda S, Terragni PP, Vejen M, Weber-Carstens S, Welte T, Gama de Abreu M, Pelosi P, Schultz MJ; ReVA Research Network and the PROVE Network Investigators. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: Mechanical ventilation during ECMO. Intensive Care Med. 2016 Nov;42(11):1672-1684.
  • Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, Protti A, Gotti M, Chiurazzi C, Carlesso E, Chiumello D, Quintel M. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med. 2016 Oct;42(10):1567-1575. doi: 10.1007/s00134-016-4505-2.
  • Quintel M, Gattinoni L, Weber-Carstens S. The German ECMO inflation: when things other than health and care begin to rule medicine. Intensive Care Med. 2016 Aug;42(8):1264-6. doi: 10.1007/s00134-016-4380-x. Epub 2016 Jun 6. PubMed PMID: 27272677.
  • Gattinoni L, Quintel M. How ARDS should be treated. Crit Care. 2016 Apr 6;20:86. doi: 10.1186/s13054-016-1268-7. PubMed PMID: 27048605; PubMed Central PMCID: PMC4822276.
  • Bein T, Grasso S, Moerer O, Quintel M, Guerin C, Deja M, Brondani A, Mehta S. The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia. Intensive Care Med. 2016 May;42(5):699-711. doi: 10.1007/s00134-016-4325-4.
  • Pesenti A, Musch G, Lichtenstein D, Mojoli F, Amato MBP, Cinnella G, Gattinoni L, Quintel M. Imaging in acute respiratory distress syndrome. Intensive Care Med. 2016 May;42(5):686-698. doi: 10.1007/s00134-016-4328-1.
  • Fan E, Gattinoni L, Combes A, Schmidt M, Peek G, Brodie D, Muller T, Morelli A, Ranieri VM, Pesenti A, Brochard L, Hodgson C, Van Kiersbilck C, Roch A, Quintel M, Papazian L. Venovenous extracorporeal membrane oxygenation for acute respiratory failure : A clinical review from an international group of experts. Intensive Care Med. 2016 May;42(5):712-724. doi: 10.1007/s00134-016-4314-7.
  • Moerer O, Quintel M. Bridge or Abyss: Extracorporeal Membrane Oxygenation for Acute Respiratory Failure in Interstitial Lung Disease. Am J Respir Crit Care Med. 2016 Mar 1;193(5):474-6. doi: 10.1164/rccm.201511-2184ED. PubMed PMID: 26930427.
  • Gattinoni L, Quintel M. Is mechanical ventilation a cure for ARDS? Intensive Care Med. 2016 May;42(5):916-917. doi: 10.1007/s00134-016-4266-y. Epub 2016 Feb 18. PubMed PMID: 26891674.
  • Fanelli V, Ranieri MV, Mancebo J, Moerer O, Quintel M, Morley S, Moran I, Parrilla F, Costamagna A, Gaudiosi M, Combes A. Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome. Crit Care. 2016 Feb 10;20:36. doi: 10.1186/s13054-016-1211-y.
  • Gattinoni L, Marini JJ, Pesenti A, Quintel M, Mancebo J, Brochard L. The "baby lung" became an adult. Intensive Care Med. 2016 May;42(5):663-673. doi:10.1007/s00134-015-4200-8.

2015

  • Brandstetter S, Dodoo-Schittko F, Blecha S, Sebök P, Thomann-Hackner K, Quintel M, Weber-Carstens S, Bein T, Apfelbacher C. Influence of quality of care and individual patient characteristics on quality of life and return to work in survivors of the acute respiratory distress syndrome: protocol for a prospective, observational, multi-centre patient cohort study (DACAPO). BMC Health Serv Res. 2015 Dec 17;15:563. doi: 10.1186/s12913-015-1232-2. PubMed PMID: 26677970; PubMed Central PMCID: PMC4683730.
  • Moerer O, Brodie D, Quintel M. Low-Flow Extracorporeal Carbon Dioxide Removal. Moving Closer to Reality. Am J Respir Crit Care Med. 2015 Sep 15;192(6):651-2. doi: 10.1164/rccm.201506-1181ED. PubMed PMID: 26371808.
  • Riech S, Kallenberg K, Moerer O, Hellen P, Bärtsch P, Quintel M, Knauth M. The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema. Crit Care Med. 2015 Sep;43(9):e386-9. doi: 10.1097/CCM.0000000000001150. PubMed PMID: 26110491.
  • Caironi P, Carlesso E, Cressoni M, Chiumello D, Moerer O, Chiurazzi C, Brioni M, Bottino N, Lazzerini M, Bugedo G, Quintel M, Ranieri VM, Gattinoni L. Lung recruitability is better estimated according to the Berlin definition of acute respiratory distress syndrome at standard 5 cm H2O rather than higher positive end-expiratory pressure: a retrospective cohort study. Crit Care Med. 2015 Apr;43(4):781-90. doi: 10.1097/CCM.0000000000000770.

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