Logo Universitätsmedizin Göttingen
Forschung > Schwerpunkte > Personalisierte Medizin

AG Personalisierte Medizin

Aktuelle Projekte

  • Einfluss genetischer Polymorphismen der angeborenen Immunität auf das Outcome septischer Patienten
  • Früherkennung von Infektionen mittels zur Erfassung der körpereigenen Immunreaktion (Förderung durch die Stanford University)
  • Immunomonitoring bei kritisch Kranken Patienten auf der Intensivstation unter Anwendung von CyTOF (time-of-flight mass spectrometry), (Förderung durch die Volkswagenstiftung und die GIF (German-Israeli Foundation for Scientific Research and Development)

Team

Arbeitsgruppenleiter

Priv.-Doz. Dr. med. Ashham Mansur

Kontaktinformationen

Mitglieder

  • PD Dr. med. Ingo Bergmann (Klinik für Anästhesiologie, UMG)
  • Prof. Tim Beissbarth (Direktor des Instituts für Medizinische Bioinformatik der Universitätsmedizin Göttingen, UMG)
  • Dr. med. Benedikt Büttner (Klinik für Anästhesiologie, UMG)
  • Prof. Michael Ghadimi (Klinik für Allgemein-, Viszeral- und Kinderchirurgie, UMG)
  • Prof. José Hinz (Klinik für Anästhesiologie und operative Intensivmedizin, Klinikum Siloah, Hannover).
  • Herr Caspar Mewes (Klinik für Anästhesiologie, UMG)

Externe Mitglieder

  • Prof. Mladen Tzvetkov (Leiter des Instituts für für Pharmakologie, Universitätsmedizin Greifswald)
  • Prof. Aron Frederik Popov (Bereichsleitung Herzinsuffizienzchirurgie, Klinik für Herz-Thorax- & Gefäßchirurgie, Universitätsklinikum Tübingen)

Aktuelle Doktoranden

Bronja Hillebrecht, Benjamin Liese, Simon Wilmers, Yvonne Klee, Luisa von Gruben, Maximilian Steinau, Evelyn Mulwande, Kristin Ivan, Fabian Kriesel, Caspar Mewes, Julius Runzheimer, Carolin Böhnke und Tessa Alexander

Kooperationen

  • Prof. Sabine Blaschke (Ärztliche Leitung Interdisziplinäre Notaufnahme (INA), UMG)
  • Prof. Shai Shen-Orr, PhD (Associate Professor, Dept. of Immunology, Rappaport Institute of Medical Research, Faculty of Medicine and Faculty of Biology, Technion, Israel)
  • Prof. Purvesh Khatri (Associate Professor of Medicine (Biomedical Informatics Research-ITI Institute) and Biomedical Data Science, University of Stanford, CA, USA)
  • Dr. Timothy Sweeney, PhD (CEO, Inflammatix, CA, USA)

Publikationen

der letzten 5 Jahre

2019

  • Runzheimer, J., Mewes, C., Büttner, B., Hinz, J., Popov, A.-F., Ghadimi, M., Kristof, K., Beissbarth, T., Schamroth, J., Tzvetkov, M., Schmack, B., Quintel, M., Bergmann, I., Mansur, A.: Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients-A Monocentric Prospective Genetic Association Study. J Clin Med 2019, 8.
  • Mewes, C., Büttner, B., Hinz, J., Alpert, A., Popov, A.-F., Ghadimi, M., Beissbarth, T., Tzvetkov, M., Jensen, O., Runzheimer, J., Quintel, M., Shen-Orr, S., Bergmann, I., Mansur, A.: CTLA-4 Genetic Variants Predict Survival in Patients with Sepsis. J Clin Med 2019, 8.

2018

  • Kristof, K., Büttner, B., Grimm, A., Mewes, C., Schmack, B., Popov, A.F., Ghadimi, M., Beissbarth, T., Hinz, J., Bergmann, I., Mansur, A.: Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis. BMC Res Notes 2018, 11, 879.
  • Mewes, C., Büttner, B., Hinz, J., Alpert, A., Popov, A.F., Ghadimi, M., Beissbarth, T., Tzvetkov, M., Shen-Orr, S., Bergmann, I., Mansur, A.: The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis. Sci Rep 2018, 8, 15140.
  • Schmack, B., Grossekettler, L., Weymann, A., Schamroth, J., Sabashnikov, A., Raake, P.W., Popov, A.F., Mansur, A., Karck, M., Schwenger, V., Ruhparwar, A.: Prognostic relevance of hemodialysis for short-term survival in patients after LVAD implantation. Sci Rep 2018, 8, 8546.
  • Schmack, B., Farag, M., Kremer, J., Grossekettler, L., Brcic, A., Raake, P.W., Kreusser, M.M., Goldwasser, R., Popov, A.-F., Mansur, A., Karck, M., Ruhparwar, A.: Results of concomitant groin-free percutaneous temporary RVAD support using a centrifugal pump with a double-lumen jugular venous cannula in LVAD patients. Journal of Thoracic Disease 2018, 3.
  • Büttner, B., Dracklé, J., Kristof, K., Hinz, J., Schwarz, A., Bauer, M., Mansur, A., Bergmann, I.: Paths of femoral nerve catheters placed using ultrasound-guided in plane vs out of plane techniques: A randomized controlled clinical trial. Medicine 2018, 97.
  • Büttner, B., Mansur, A., Kalmbach, M., Hinz, J., Volk, T., Szalai, K., Roessler, M., Bergmann, I.: Prehospital ultrasound-guided nerve blocks improve reduction-feasibility of dislocated extremity injuries compared to systemic analgesia. A randomized controlled trial. PLoS ONE 2018, 13.
  • Ananiadou, O., Schmack, B., Zych, B., Sabashnikov, A., Garcia-Saez, D., Mohite, P., Weymann, A., Mansur, A., Zeriouh, M., Marczin, N., De Robertis, F., Simon, A.R., Popov, A.-F.: Suicidal hanging donors for lung transplantation: Is this chapter still closed? Midterm experience from a single center in United Kingdom. Medicine 2018, 97.
  • Acharya, M.N., El-Diasty, M., Schmack, B., Weymann, A., Mansur, A., Popov, A.-F.: Severe bilateral isolated coronary ostial lesions as a rare manifestation of radiation-induced cardiac disease A case report. Medicine 2018, 97.
  • Bergmann, I., Büttner, B., Teut, E., Jacobshagen, C., Hinz, J., Quintel, M., Mansur, A., Roessler, M.: Pre-hospital transthoracic echocardiography for early identification of non-ST-elevation myocardial infarction in patients with acute coronary syndrome. Crit Care 2018, 22, 29.
  • Hinz, J., Büttner, B., Kriesel, F., Steinau, M., Frederik Popov, A., Ghadimi, M., Beissbarth, T., Tzvetkov, M., Bergmann, I., Mansur, A.: The FER rs4957796 TT genotype is associated with unfavorable 90-day survival in Caucasian patients with severe ARDS due to pneumonia. Sci Rep 2018, 7.

2017

  • Zeriouh, M., Sabashnikov, A., Patil, N.P., Schmack, B., Zych, B., Mohite, P.N., García Sáez, D., Koch, A., Mansur, A., Soresi, S., Weymann, A., Marczin, N., Wahlers, T., De Robertis, F., Simon, A.R., Popov, A.-F.: Use of taurolidine in lung transplantation for cystic fibrosis and impact on bacterial colonization. Eur J Cardiothorac Surg 2017, 53, 603–609.
  • Schmack, B., Seppelt, P., Weymann, A., Alt, C., Farag, M., Arif, R., Doesch, A.O., Raake, P.W., Kallenbach, K., Mansur, A., Popov, A.-F., Karck, M., Ruhparwar, A.: Extracorporeal life support with left ventricular decompression-improved survival in severe cardiogenic shock: results from a retrospective study. PeerJ 2017, 5.
  • Büttner, B., Mansur, A., Hinz, J., Erlenwein, J., Bauer, M., Bergmann, I.: Combination of general anesthesia and peripheral nerve block with low-dose ropivacaine reduces postoperative pain for several days after outpatient arthroscopy: A randomized controlled clinical trial. Medicine 2017, 96.

2016

  • Büttner, B., Mansur, A., Bauer, M., Hinz, J., Bergmann, I.: Einseitige Spinalanästhesie: Literaturübersicht und Handlungsempfehlung. Anaesthesist 2016, 65, 847–865.
  • Erlenwein, J., Thoms, K.-M., Brandebusemeyer, F., Pfingsten, M., Mansur, A., Quintel, M., Schön, M.P., Petzke, F.: Pre-Existing Chronic Pain Influences the Severity of Acute Herpes Zoster Pain-A Prospective Observational Cohort Study. Pain Med 2016.
  • Soresi, S., Zeriouh, M., Sabashnikov, A., Sarang, Z., Mohite, P.N., Patil, N.P., Mansur, A., Weymann, A., Wippermann, J., Wahlers, T., Reed, A., Carby, M., Simon, A.R., Popov, A.-F.: Extended Recipient Criteria in Lung Transplantation: Impact of Pleural Abnormalities on Primary Graft Dysfunction. Ann. Thorac. Surg. 2016, 101, 2112–2119.
  • Hinz, J., Mansur, A., Hanekop, G.G., Weyland, A., Popov, A.F., Schmitto, J.D., Grüne, F.F.G., Bauer, M., Kazmaier, S.: Influence of isoflurane on the diastolic pressure-flow relationship and critical occlusion pressure during arterial CABG surgery: a randomized controlled trial. PeerJ 2016, 4.

2015

  • Mansur, A., Popov, A.F., Abu Hanna, A., Bergmann, I., Brandes, I.F., Beissbarth, T., Bauer, M., Hinz, J.: Perioperative Blood Glucose Levels <150 mg/dL are Associated with Improved 5-Year Survival in Patients Undergoing On-Pump Cardiac Surgery: A Prospective, Observational Cohort Study. Medicine 2015, 94.
  • Mansur, A., Steinau, M., Popov, A.F., Milenovic, S., Bireta, C., Weymann, A., Schotola, H., Wiese, C.H., Beissbarth, T., Tzvetkov, M., Hinz, J.: Genetic Polymorphisms in Endothelin-1 as Predictors for Long-Term Survival and the Cardiac Index in Patients Undergoing On-Pump Cardiac Surgery. PLoS ONE 2015, 10.
  • Mansur, A., Steinau, M., Popov, A.F., Ghadimi, M., Beissbarth, T., Bauer, M., Hinz, J.: Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study. BMC Medicine 2015, 13.
  • Mansur, A., Liese, B., Steinau, M., Ghadimi, M., Bergmann, I., Tzvetkov, M., Popov, A.F., Beissbarth, T., Bauer, M., Hinz, J.: The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study. PLoS One 2015, 10. Hab.
  • Mansur, A., Mulwande, E., Steinau, M., Bergmann, I., Frederik Popov, A., Ghadimi, M., Beissbarth, T., Bauer, M., Hinz, J.: Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis. Sci Rep 2015, 5.
  • Ross, D., Hinz, J., Mansur, A., Mielck, F., Roessler, M., Quintel, M., Bauer, M.: Implementierung eines neuen Schockraumprotokolls an einem Universitätsklinikum in Deutschland. Anaesthesist 2015, 64, 208–217.
  • Schotola, H., Kirsch, K.-C., Höcker, J., Egan, M., Büttner, B., Wiese, C., Mansur, A., Hinz, J.M., Bergmann, I.: Ketamine in outpatient arthroscopic shoulder surgery: Effects on postoperative pain, hemodynamic stability and process times. Open Med 2015, 10, 297–305.
  • Mansur, A., Klee, Y., Popov, A.F., Erlenwein, J., Ghadimi, M., Beissbarth, T., Bauer, M., Hinz, J.: Primary bacteraemia is associated with a higher mortality risk compared with pulmonary and intra-abdominal infections in patients with sepsis: a prospective observational cohort study. BMJ Open 2015, 5.

Das könnte Sie auch interessieren

Folgen Sie uns